Key result
Fluoxetine prolongs bleeding time and inhibits platelet aggregation in mice, reversing after 14-day withdrawal.
Why the study?
Fluoxetine induces adverse effects including bleeding events, but the action cascade leading to a longer bleeding time required clarification.
Does fluoxetine prolong bleeding time and alter platelet function in male adult mice?
Population
48 male adult mice
Comparison
Fluoxetine at 4, 8, or 16 mg/kg vs 0 mg/kg (saline)
Design
Preclinical animal study
Follow-up
Day 29
Authors
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Reversible platelet effects in mice support further hemostasis research; leaves open human clinical relevance pending prospective studies.
Does fluoxetine prolong bleeding time and alter platelet function in male adult mice?
p-value: p=< 0.01
Fluoxetine prolongs bleeding time in mice through a pathway involving decreased intraplatelet serotonin, increased GPIbα shedding, suppressed GPIIb/IIIa activation, and inhibited α-granule release.
Li et al. (2020) studied this question. Fluoxetine vs. Saline (0 mg/kg) was evaluated on Bleeding time (p=< 0.01). Fluoxetine significantly prolonged bleeding time in mice (P < 0.01) and inhibited platelet aggregation, with all changes returning to control levels after a 14-day withdrawal.
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