A number of substances have been found which can replace 2:4-dichlorophen-oxyacetic acid (2:4-D) as a synergist with coconut milk in stimulating the growth of potato tuber tissue in culture. Two of these compounds, viz. α-(2-naphthoxy)-and α-(2: 4: 5-trichlorophenoxy)-propionic acids, are optically active and their (+)- and (−)-enantiomorphs have also been examined for synergistic activity. In each case the (+)-form was found to be highly active and the (−)-form inactive. Evidence is also presented showing that the inactive (−)-isomer of a-(2-naphthoxy)propionic acid can depress the synergistic activity of the (+)-isomer and it is suggested that this occurs by competitive antagonism.
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Shantz et al. (1955) studied this question.