Key result
Recent advances identify new interferon-stimulated gene effectors and mechanisms protecting cells from viral pathogens.
This review summarizes recent advances in understanding the mechanisms and in vivo relevance of various interferon-stimulated genes in antiviral defense.
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May guide antiviral strategies; leaves open clinical translation of these ISG effectors.
The interferon response protects cells from invading viral pathogens by transcriptionally inducing the expression of interferon-stimulated genes (ISGs), some of which encode effectors with varied antiviral functions. As screening technologies improve and mouse model development quickens, more ISGs are continually being identified, characterized mechanistically, and evaluated for protective rolesin vivo. This review highlights selected recent findings of ISG effectors that contribute to our understanding of the interferon antiviral response.
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John W. Schoggins (2018) conducted a review in Viral infection. Interferon-stimulated genes (ISGs) was evaluated. Recent advances in antiviral interferon-stimulated gene biology highlight the identification of new ISG effectors and their mechanisms in protecting cells from invading viral pathogens.
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