Key result
Experimental aortic clamping yields ~75% higher IL-6 levels at the heart versus the posterior cava vein.
Why the study?
Does the intestinal tract or hind limbs act as the major source of IL-6 production during abdominal aortic clamping and hind limb ischemia-reperfusion injury in Wistar rats?
Does the intestinal tract or hind limbs act as the major source of IL-6 production during abdominal aortic clamping and hind limb ischemia-reperfusion injury in Wistar rats?
p-value: p=<0.001
The splanchnic region is a significant source of the inflammatory response secondary to ischemia and reperfusion of the hind limbs in a rat model.
May reflect splanchnic IL-6 contribution in rat aortic clamping; leaves open primary source and clinical translation.
PURPOSE: The aim of this study was to investigate whether the hind limbs or intestinal tract is the most important initiator of the inflammatory response secondary aortic clamping and hind limb ischemia/reperfusion injury. METHODS: Blood samples of Wistar rats obtained from posterior cava vein, portal vein, and heart cavity during either laparotomy (control group, n=8) or laparotomy + 2 h of aortic clamping and bilateral hind limb ischemia (ischemia group, n=8), or 2 h after ischemia and 2 h of reperfusion (ischemia-reperfusion group, n=8) were assayed for interleukin 6 (IL-6) and C-reactive protein (CRP). RESULTS: Serum IL-6 at the heart (223.6+/-197.9 [10-832] pg/mL) was higher (p<0.001) than at both portal (133.08+/-108.52 [4-372] pg/mL) and posterior cava veins (127.58+/-109.15 [8-388] pg/mL). CRP was not significant different among groups. CONCLUSION: The splanchnic region is also a source of inflammatory response secondary to ischemia and reperfusion of the hind limbs.
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Pimenta et al. (2007) studied Abdominal aortic clamping and hind limb ischaemia-reperfusion injury (n=24). Aortic clamping and bilateral hind limb ischemia/reperfusion vs. Laparotomy alone was evaluated on Serum interleukin 6 (IL-6) and C-reactive protein (CRP) (p=<0.001). Serum IL-6 levels at the heart (223.6 pg/mL) were significantly higher than at the portal (133.08 pg/mL) and posterior cava veins (127.58 pg/mL) (p<0.001).
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