UNTIL the discovery of penicillin, the methods of treating the infectious arthritides were not entirely satisfactory. Although the sulfonamides were often valuable, the results obtained with them left much to be desired. The superior antibacterial action of penicillin in vitro justified a trial of this agent in certain bacterial infections of the joints. The present report is an account of our experience with penicillin in the treatment of 26 patients with bacterial arthritis.Gonococcal ArthritisSeventeen patients with gonococcal arthritis were treated with penicillin (Table 1). The diagnosis was made in 9 cases by culturing gonococci from the joint fluid . . .
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Hirsh et al. (1946) studied this question.