Key result
Mars peristaltic pump demonstrates acceptable blood injury performance vs HP-6 with ~0.15 g/L free plasma hemoglobin.
p-value: p=<0.001
The study presents a new approach for conducting preclinical hydrodynamic and functional tests of mechatronic peristaltic blood pumps prior to animal experiments.
Acceptable hemolysis supports preclinical pump testing; leaves open clinical translation pending human data.
The article considers the results of scientific research works on creation of hydrodynamic and functional experimental benches for pre-clinical physiological tests of new mechatronic peristaltic blood pumps. The conclusion states the need in carrying out such tests before the start of biological experiments involving animals. An example of the device developed at Central Research Institute of Robotics and Cybernetics-a centrifugal pump-having optimal physiological characteristics is provided. The novelty of the proposed approaches to creation of hydrodynamic and functional experimental benches, as well as their technical equipment and data obtained as a result of the experiments, form a new approach to conduct of preclinical and physiological tests of mechatronic peristaltic pumps.
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Lopota et al. (2016) studied Preclinical blood pump testing (n=20). Mars peristaltic pump vs. HP-6 peristaltic pump was evaluated on Free plasma hemoglobin content (p=<0.001). After 4 hours of whole blood perfusion, the Mars peristaltic pump resulted in a free plasma hemoglobin level of 0.154 g/L, demonstrating acceptable blood injury performance compared to the HP-6 pump.
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