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May 8, 2002Biochemical JournalOpen Access

Primary arrest of circulating platelets on collagen involves phosphorylation of Syk, cortactin and focal adhesion kinase: studies under flow conditions

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Key result

Initial platelet adhesion drives GPIb-dependent Syk phosphorylation prior to cortactin, FAK, and GPIIb-IIIa activation.

Population

Platelets/blood samples under flow conditions, including blood from two patients with Glanzmann's…

Design

Preclinical

Authors

GAGemma ArderiuMDMaribel Díaz‐RicartBBByron R. Buckley

Discussion

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Overview

Clarifies early platelet signaling under flow; leaves open whether Syk or FAK inhibition alters thrombosis in vivo.

Structured PICO

P
Population
Platelets/blood samples under flow conditions, including blood from two patients with Glanzmann's thrombasthenia
I
Intervention
Exposure to acetylsalicylic acid or monoclonal antibody specific for GPIIb-IIIa
O
Outcome
Tyrosine-phosphorylation patterns (Syk, cortactin, FAK) during platelet adhesionsurrogate

The initial arrest of platelets on subendothelial components involves GPIb-dependent Syk phosphorylation, followed by activation of cortactin and FAK prior to GPIIb-IIIa activation.

Cite This Study

Arderiu et al. (2002) studied this question. Acetylsalicylic acid and GPIIb-IIIa monoclonal antibody was evaluated on Tyrosine-phosphorylation patterns during platelet adhesion. Initial arrest of platelets on subendothelial components involves GPIb-dependent Syk phosphorylation, followed by activation of cortactin and focal adhesion kinase before GPIIb-IIIa activation.

synapsesocial.com/papers/6aa20b1657affa4c5d46eddbhttps://doi.org/10.1042/bj3640065
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Linkage of a membrane skeleton to integral membrane glycoproteins in human platelets. Identification of one of the glycoproteins as glycoprotein Ib.1985 · 172 citations
  2. 2Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA1973 · 6,920 citations
  3. 3A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia1987 · 273 citations
  4. 4Activation of the GP IIb-IIIa Complex Induced by Platelet Adhesion to Collagen Is Mediated by Both α2β1 Integrin and GP VI1999 · 86 citations
  5. 5The α2β1 Integrin Is a Necessary Co-receptor for Collagen-induced Activation of Syk and the Subsequent Phosphorylation of Phospholipase Cγ2 in Platelets1996 · 158 citations