Key result
Decreased arterial compliance increases IABC performance by ~35% in an in vitro model.
Why the study?
Does arterial compliance affect the effectiveness of intra-aortic balloon counterpulsation in an in vitro model?
Population
In vitro Windkessel, lumped-element, hydraulic model of the systemic circulation
Design
Preclinical
Authors
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Reduced arterial compliance may enhance IABP performance in vitro; hypothesis-generating and requires clinical validation before practice change.
Does arterial compliance affect the effectiveness of intra-aortic balloon counterpulsation in an in vitro model?
Effect estimate: 30-40% increase
In an in vitro model, decreased arterial compliance significantly improved the hemodynamic efficacy of intra-aortic balloon counterpulsation.
Papaioannou et al. (2002) studied this question. Decreased arterial compliance vs. Baseline arterial compliance was evaluated on Indices of IABC performance (reduction of systolic and end-diastolic arterial pressure and augmentation of diastolic pressure) (30-40% increase). A 22% decrease in arterial compliance (1.8 to 1.4 ml/mmHg) in an in vitro model led to a 30-40% increase in indices of intra-aortic balloon counterpulsation performance.
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