One, two or three? The utilization of sterically hindered alkyl substrates represents a major challenge of the present cross-coupling methodology. The nickel-catalyzed Kumada cross- coupling of tertiary alkyl Grignard reagents with aryl bromides allows this difficult reaction with numerous different substrates. Optimal results were obtained using sterically demanding, bifunctional N-heterocyclic carbene ligands.
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Lohre et al. (2011) studied this question.
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