L‐Dopa produced a significant reduction in recumbent and standing blood pressure in patients with neurologic or psychiatric disorders. The addition of an extracerebral decarboxylase inhibitor potentiated this effect. Reflex forearm arteriolar and venous constriction was present during therapy with L‐dopa alone or in combination with the decarboxylase inhibitor, but there was an attenuation of reflex forearm arteriolar constriction. It is suggested that the hypotensive effect of L‐dopa may be mediated through the central nervous system.
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Watanabe et al. (1970) studied this question.