Key result
Higher strain-rates fail to increase tissue stress in native porcine valves and treated pericardium.
Why the study?
To evaluate the rate-dependent and relaxation properties of native porcine heart valves, glutaraldehyde fixed porcine pericardium, and decellularized sterilized porcine pericardium.
Increasing strain-rate does not increase tissue stress in porcine heart valve biomaterials, indicating accelerated wear testing may not artificially increase fatigue compared to physiological loading.
No takes yet. Share an insight, caveat, or question.
Accelerated wear testing of valve biomaterials may remain valid without inflated stress; leaves open in vivo human validation.
Noble et al. (2020) studied Aortic valve replacement biomaterials (n=38). Varying strain-rates (0.001 to 1 s-1) vs. Physiological strain-rates was evaluated on Stress within the tissue at varying strain-rates. Increasing the strain-rate of native porcine valves, glutaraldehyde fixed pericardium, and decellularized pericardium does not significantly increase tissue stress.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: