In‐Situ Incorporation of Amoxicillin in PVA/PVAc‐co‐PMMA Particles during Suspension Polymerizations

Embolization is a radiological technique that consists in occluding a blood vessel intentionally with an embolic agent (particle). A suspension polymerization process was developed to allow for production of embolic particles with core‐shell morphology. This technology was modified to allow for the in‐situ incorporation of antibiotics (amoxicillin) in PVA/PVAc‐co‐PMMA core‐shell particles. The incorporation of amoxicillin led to modification of some of the final polymer properties, including the particle morphology, the molecular weight distribution and the characteristic transition temperatures of the polymer material. The final polymer properties depended on the antibiotic concentration and on how the drug was added into the polymerization medium.