Hemoglobin Variant Common to Chinese and North American Indians: α 2 β 2 22Glu→Ala

An electrophoretically slow hemoglobin variant, in which the structural change involves the replacement of a glutamyl residue by alanyl at position beta-22, was reported in two groups of North American Indians: hemoglobin-G Coushatta, in Alabama-Coushatta Indians in Texas; and hemoglobin-G Saskatoon, in descendants of Santee Indians living in Canada. Hemoglobin-G Hsin-Chu, found in Taiwan in a Chinese from the northern Chinese province of Liaoning, is now shown to have the same structural anomaly.