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Unmodified gold nanoparticles (GNPs) can be wrapped with long genomic single- and double-stranded DNA (ssDNA and dsDNA) molecules produced by asymmetric polymerase chain reaction (As-PCR). More importantly, the DNA-Au interaction can be utilized for colorimetric detection of a specific nucleic acid sequence in clinical samples.
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Deng et al. (2012) studied this question.
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