Key result
Injection of mitosis-promoting factor into Xenopus oocytes expressing rat eag potassium channels induces a dramatic reduction in current amplitude.
Population
Xenopus oocytes expressing rat eag (R-eag) potassium channels
Design
Preclinical
Authors
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Should not yet inform clinical channelopathy management; hypothesis-generating for cell-cycle regulation of eag currents in mammalian cardiomyocytes.
Mitosis-promoting factor specifically inhibits heterologously expressed rat eag potassium channels during oocyte maturation.
Brüggemann et al. (1997) studied this question. Mitosis-promoting factor injection was evaluated on Current amplitude of R-eag potassium channels. Injection of mitosis-promoting factor into Xenopus oocytes expressing rat eag potassium channels induces a dramatic reduction in current amplitude.
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