In vitro study demonstrates synergistic activity of gentamicin combinations against multidrug-resistant Neisseria gonorrhoeae, highlighting viable candidates for clinical therapy testing.
susceptibility against clinical gonococcal isolates collected in 2016 and 2017, including MDR isolates. Combinations of gentamicin plus ertapenem, ceftriaxone, and azithromycin produced synergistic effects against certain MDR isolates. No antagonism was observed in any of the antimicrobial combinations, which may prove useful to guide clinical testing of combination therapies.
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