Fusarin C, (7Z)-Fusarin C and (5Z)-Fusarin C; Inhibitors of Dihydroxynaphthalene-melanin Biosynthesis from Nectria coccinea (Cylindrocarpon sp.).

In Ascomycotina and related Deuteromycotina, the dark-brown to black pigments in cell walls are generally synthesized via the pentaketide pathway with 1,8dihydroxynaphthalene (DHN) as a precursor1}.DHN melanin has been implicated as a pathogenicity factor in fungal plant diseases and animal mycoses2).Inhibitors of melanin biosynthesis like tricyclazole, pyroquilone or fthalide are used to prevent rice blast disease caused by Pyricularia oryzae3).