Abstract magnified image A polyurea‐encapsulated palladium catalyst (Pd EnCatTM 30) was first applied to Sonogashira cross‐coupling reactions in the absence of a copper salt co‐catalyst and under phosphine‐free conditions. This polymer‐anchored homogeneous palladium catalyst efficiently catalyzed the Sonogashira reaction of various iodoarenes with terminal alkynes in H2O/MeCN, and good yields were obtained at 40° after 3–7 h in the presence of piperidine. Moreover, this catalyst maintains its efficiency through three recycle runs.
No takes yet. Share an insight, caveat, or question.
Kuang et al. (2009) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: