Key result
Densely sulfated heparan sulfate analogues inhibit EV71 infection by acting as viral capsid decoy receptors.
Why the study?
Enterovirus 71 is a major cause of hand, foot, and mouth disease, but there is no antiviral therapy available.
Answers are grounded in this paper and cite their sources.
Densely sulfated disaccharide heparan sulfate analogues act as potent decoy receptors to block EV71 infection without significant anticoagulant activity.
Enterovirus 71 (EV71) is a major etiological agent of hand, foot, and mouth disease, for which there is no antiviral therapy. We have developed densely sulfated disaccharide heparan sulfate (HS) analogues that are potent small molecule inhibitors of EV71 infection, binding to the viral capsid and acting as decoy receptors to block early events of virus replication. The simplified structures, more potent than defined HS disaccharides and with no significant anticoagulant activity, offer promise as anti-EV71 agents.
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Earley et al. (2019) studied Enterovirus 71 (EV71) infection. Densely sulfated disaccharide heparan sulfate (HS) analogues was evaluated on Inhibition of EV71 infection. Densely sulfated disaccharide heparan sulfate analogues act as potent small molecule inhibitors of EV71 infection by binding to the viral capsid and acting as decoy receptors.
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