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An efficient method for nucleophilic (phenylsulfonyl/arylthio)difluoromethylation of aldehydes with TMSCF 2 Br was developed. The reaction proceeds through in situ generation of difluorocarbene, which is captured by PhSO 2 Na or ArSNa to form the corresponding PhSO 2 CF 2 – or PhSCF 2 – anions, followed by nucleophilic addition to aldehydes to give the desired difluoromethylated products.
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Xie et al. (2019) studied this question.
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