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HISTORICAL In 1912, Berthelot and Bertrand1described an organism which they isolated from human stools and calledBacillus aminophilus. Among other characteristics, it showed a marked ability to decarboxylate and deaminize amino-acids. Also, it was capable of producing histamine from histidine. Holmes and Rettinger2alleged that dementia praecox was caused by the production of histamine by this organism in the intestinal tract. From a study of the frequency of B.aminophilusin the stools of patients with dementia praecox, Jones3was unable to support the assumption of Holmes and Rettinger. He found: that this organism was present only in the proportion of from 1 to 20,000 to 1 to 100,000 of living bacteria; that it was found with a frequency usual in normal persons; that the histamine present was produced by other intestinal bacteria; thatB. aminophilusdid not utilize the carboxyl radical (COOH) of histidine if
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L. A. Julianelle (1923) studied this question.
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