Key result
A single 3.5-hour bout of intense swimming in rats significantly increased serum CK-MB mass immediately post-exercise (8.9 vs 4.3 microg/L, p<0.01), indicating myocardial injury.
Why the study?
Does prolonged intense exercise cause myocardial CK-MB release and CK-B alteration in a rat model?
Does prolonged intense exercise cause myocardial CK-MB release and CK-B alteration in a rat model?
Absolute Event Rate: 8.9% vs 4.3%
p-value: p=< 0.01
Prolonged intense exercise in a rat model leads to myocardial CK-B subunit loss and increased serum CK-MB, suggesting myocardial injury.
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Hypothesis-generating for exercise-induced myocardial injury; human studies needed before clinical relevance.
Chen et al. (2000) studied Myocardial injury. Forced swimming vs. Sedentary (rest) was evaluated on Serum CK-MB mass immediately post swimming (0 h PS) (p=< 0.01). A single 3.5-hour bout of intense swimming in rats significantly increased serum CK-MB mass immediately post-exercise (8.9 vs 4.3 microg/L, p<0.01), indicating myocardial injury.
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