Redox-active metal complexes for imaging hypoxic tissues: structure–activity relationships in copper(ii) bis(thiosemicarbazone) complexes

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Reduction potential and lipophilicity of the copper(II) bis(thiosemicarbazone) complexes can be independently controlled by alkylation in the diketone backbone and the N-termini of the ligand, allowing optimisation of radiopharmaceuticals strongly selective for hypoxic tissues.