Key result
Higher triglyceride-glucose index linked to ~83% greater odds of erectile dysfunction in men without CVD.
Why the study?
Insulin resistance plays a role in the pathogenesis of erectile dysfunction, and the triglyceride-glucose index is a reliable marker of insulin resistance whose role in erectile dysfunction required investigation.
Is the Triglyceride-glucose (TyG) index associated with erectile dysfunction in subjects without cardiovascular disease?
Case-Control (n=160)
No
Is the Triglyceride-glucose (TyG) index associated with erectile dysfunction in subjects without cardiovascular disease?
The TyG index, a marker of insulin resistance, is significantly elevated in patients with erectile dysfunction and correlates negatively with erectile function scores in men without cardiovascular disease.
TyG index may flag ED risk in men without CVD; leaves open clinical utility and needs prospective validation.
Objective: Studies have shown that insulin resistance (IR) plays a role in the pathogenesis of erectile dysfunction (ED).Triglyceride-glucose (TyG) index has been found as a reliable marker of IR.In this study, our aim was to investigate the role of TyG index in patients with ED. Materials and Methods: One hundred six patients with ED (study group) and 54 subjects with normal sexual function (control group) constituted our study population.Erectile function was assessed by using International Index of Erectile Function-5 (IIEF-5) questionnaire.TyG index was calculated for each participant.Results: ED patient were older, had higher total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), glucose and triglyceride concentrations and TyG indexes (p<0.001,p<0.001, p<0.001, p=0.036, p=0.026 and p=0.003, respectively).IIEF-5 scores showed a negative correlation with TyG indexes (r= -0.273, p=0.001).Receiver operating characteristic (ROC) curve analysis showed that TyG index cut-off value of 9.03 had 70.3% sensitivity and 65% specificity in predicting mild-to-moderate, moderate, and severe ED.Univariate logistic regression analysis showed that age, TC, LDL-C, and TyG index had predictive values for the identification of the patients who had mild-to-moderate, moderate, and severe ED.Conclusion: TyG index might be a valuable diagnostic tool for ED, and it might be used in clinical practice for the evaluation of patients.
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Oflar et al. (2023) conducted a case-control in Erectile Dysfunction (n=160). Triglyceride-glucose (TyG) index vs. Normal sexual function (control group) was evaluated on Prediction of mild-to-moderate, moderate, and severe erectile dysfunction (OR 1.829, 95% CI 1.012-3.281, p=<0.001). A higher triglyceride-glucose index was a significant independent predictor of mild-to-moderate, moderate, and severe erectile dysfunction (OR 1.829) in men without cardiovascular disease.
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