SummaryA modification of photodynamic inactivation for herpes simplex viruses has been developed. Low concentrations of methylene blue, when electrically reduced in the presence of HSV, and irradiated with visible light, result in an efficient loss of plaque-forming ability. The antiviral effect is dependent upon the amount of electricity applied and the concentration of dye. Superoxide anion is an important intermediate since the photodynamic inactivation is partially inhibited by superoxide dismutase.
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Swartz et al. (1979) studied this question.
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