Cytomegalovirus Mononucleosis with Severe Thrombocytopenia

Letters1 September 1973Cytomegalovirus Mononucleosis with Severe ThrombocytopeniaMILAN FIALA, M.D., HERMAN KATTLOVE, M.D., F.A.C.P., STEPHEN LEMKIN, M.D.MILAN FIALA, M.D.Search for more papers by this author, HERMAN KATTLOVE, M.D., F.A.C.P.Search for more papers by this author, STEPHEN LEMKIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-3-450 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Rubella and cytomegalovirus are frequently associated with thrombocytopenia in congenital infections. In adult viral infections thrombocytopenia has been encountered only infrequently—in rubella (1), infectious mononucleosis, and mumps but not, to our knowledge, in cytomegalovirus infections. We have treated an adult with profound thrombocytopenia associated with cytomegalovirus viremia and viruria.An 18-year-old man was admitted to Harbor General Hospital with a 3-week history of lethargy, fever, and recent bleeding from the gums. Numerous petechiae, confluent purpura on extremities, and posterior cervical adenopathy were present. His leukocyte count was 12 700 cells/mm3, with 44% neutrophils, 45% lymphocytes—60% of which...References1. MORSE E, ZINKHAM W, and JACKSON D: Thrombocytopenic purpura following rubella infection in children and adults. Arch Intern Med 117:573-579, 1966 CrossrefMedlineGoogle Scholar2. KLEMOLA E and KAARIAINEN L: Cytomegalovirus as a possible cause of a disease resembling infectious mononucleosis. Br Med J 2:1099-1102, 1965 CrossrefMedlineGoogle Scholar3. OSBORN J and SHAHIDI N: Thrombocytopenia in murine cytomegalovirus infection. J Lab Clin Med 81:53-63, 1973 MedlineGoogle Scholar4. OSKI F and NAIMAN J: Effect of live measles vaccine on the platelet count. N Engl J Med 275:352-356, 1966 CrossrefMedlineGoogle Scholar5. MYLLYLA G, VAHERI A, and VESIKARI T: Interaction between human blood platelets, viruses and antibodies. Clin Exp Immunol 4:323-332, 1967 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MILAN FIALA, M.D.; HERMAN KATTLOVE, M.D., F.A.C.P.; STEPHEN LEMKIN, M.D.Affiliations: Division of Infectious Disease Harbor General Hospital Torrance, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCharacteristics and outcomes of adults with cytomegalovirus‐associated thrombocytopenia: a case series and literature reviewDevelopmental MegakaryocytopoiesisCytomegalovirus-associated thrombocytopenia treated with thrombopoietin receptor agonistDeep Vein Thrombosis as Debut of Cytomegalovirus Infection Associated With Type II Cryoglobulinemia, With Antierythrocyte Specificity in a Kidney Transplant Recipient: A Case ReportSevere Steroid-resistant Thrombocytopenia Secondary to Cytomegalovirus Infection in an Immunocompetent AdultDevelopmental MegakaryocytopoiesisCMV-related thrombocytopenia treated with foscarnet: A case series and review of the literatureCytomegalovirus can make immune thrombocytopenic purpura refractoryCYTOMEGALOVIRUSThrombocytopenia due to cytomegalovirus infection in an immunocompetent adultCytomegalovirus-induced thrombocytopenia in an immunocompetent adult effectively treated with intravenous immunoglobulin: A case report and reviewDevelopmental Megakaryocytopoiesis in Fetal and Neonatal PhysiologySevere thrombocytopenia secondary to cytomegalovirus infection in an immunocompetent adultInitial transforming event in myelodysplastic syndromes may be viral: case for cytomegalovirusFas-Mediated Apoptosis of the Hematopoietic Progenitor Cells in Mice Infected With Murine CytomegalovirusFas-Mediated Apoptosis of the Hematopoietic Progenitor Cells in Mice Infected With Murine CytomegalovirusCytomegalovirus as a Cause of PancytopeniaPlatelet Membrane Glycoprotein IIb/IIIa has Sequence Homologies with Human Virus Proteins and Synthetic Viral Peptides Inhibit Anti-GPIIb/IIIa Antibodies in Autoimmune Thrombocytopenic PurpuraCytomegalovirus infection in the pregnant womanThe Pathogenicity of Human Cytomegalovirus: An OverviewSevere thrombocytopenia secondary to asymptomatic cytomegalovirus infection in an immunocompetent host.The status of CMV as a human pathogenHematologic Aspects of Malignant Lymphoproliferative DiseaseGranulopénie et infection à CytomégalovirusIntranuclear inclusions in megakaryocytes in congenital cytomegalovirus infectionCytomegalovirus-Induced Thrombocytopenia and Hemolysis in an AdultALLAN I. HARRIS, M.D., RICHARD J. MEYER, M.D., EUGENE A. BRODY, M.D., F.A.C.P. 1 September 1973Volume 79, Issue 3Page: 450-451KeywordsCytomegalovirus infectionFeversHemorrhageMumpsNeutrophilsRubellaViremia ePublished: 1 December 2008 Issue Published: 1 September 1973 PDF downloadLoading ...