The chemical synthesis of 99% enriched D(‐)‐[1,7‐13C2]shikimic acid from [1,2‐13C2]acetate in 25% overall yield is described. A two‐carbon phosphonate synthon was prepared from [1,2‐13C2]acetate and used in the shikimate synthesis of Fleet and coworkers.
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Cho et al. (1992) studied this question.
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