Key result
Caucasian T2D patients have ~47% higher LDL post-ACS than matched Chinese patients.
Why the study?
Population means of conventional cardiovascular biomarkers differ across ethnic groups, but detailed comparisons of their temporal patterns between Caucasian and Chinese diabetic patients after ACS were lacking.
Do temporal changes in established cardiovascular biomarkers after ACS differ between Caucasian and Chinese patients with diabetes mellitus?
Observational (n=96)
Do temporal changes in established cardiovascular biomarkers after ACS differ between Caucasian and Chinese patients with diabetes mellitus?
Absolute Event Rate: 2.16% vs 1.47%
p-value: p=<0.001
Caucasian patients with diabetes have systematically higher levels of LDL, total cholesterol, TnT, and CRP compared to matched Chinese patients in the post-ACS period, suggesting potential need for population-specific secondary prevention targets.
May inform ethnicity-specific post-ACS monitoring in diabetes; extends biomarker comparisons but leaves open clinical outcome implications.
Background: Population means of conventional cardiovascular biomarkers are known to differ between ethnic groups. In this study we performed detailed comparisons in the temporal pattern of these biomarkers between Caucasian and Chinese diabetic patients with acute coronary syndrome (ACS).Methods: We studied differences in temporal changes of established cardiovascular biomarkers, including high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, cardiac Troponin T (TnT), NT-proBNP and C-reactive protein (CRP), in 48 Chinese and 48 clinically matched Caucasian patients with type 2 diabetes mellitus who were admitted for ACS. Blood samples were collected at regular time intervals during 30 days to 1 year after the index ACS.Results: In the >30 day post ACS period, mean serum levels of LDL (2.16 vs. 1.47 mmol/L; p-value <0.001), total cholesterol (4.08 vs. 3.11 mmol/L; p-value <0.001), TnT (11.0 vs. 7.76 ng/L; p-value 0.010) and CRP (2.0 vs. 0.78 mg/L; p-value <0.001) were systematically higher in Caucasian than in Chinese patients. HDL and NT-proBNP levels were similar.Conclusions: Our study showed clinically relevant differences in levels of established cardiovascular biomarkers between Caucasian and Chinese post ACS patients. Further cross-ethnic studies are warranted to determine secondary prevention treatment biomarker targets in specific populations.
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Buljubasic et al. (2020) conducted an observational in Acute coronary syndrome with type 2 diabetes mellitus (n=96). Caucasian ethnicity vs. Chinese ethnicity was evaluated on Mean serum LDL level >30 days post ACS (mmol/L) (p=<0.001). Caucasian patients with type 2 diabetes and ACS had higher mean serum levels of LDL (2.16 vs 1.47 mmol/L), total cholesterol, TnT, and CRP >30 days post-ACS compared to matched Chinese patients.
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