Synthesis and Antifungal Activity of Novel Bis(dithiocarbamate) Derivatives of Glycerol

Three bis(dithiocarbamate) derivatives of glycerol were obtained in 30−95% yields by reaction of a dithiocarbamic acid salt with 1,3-dichloro-1,3-dideoxyglycerol. The in vitro antifungal activity of the new compounds was evaluated against Alternaria brassicae, Pseudocercosporella herpotrichoides, Septoria nodorum, and Phytophtora cinnamomi . Some of the compounds displayed greater activity than commercial fungicides. Bis( N,N -diethyldithiocarbamoyl)-1,3-dideoxyglycerol ( 4 ) was found to maintain its pesticidal activity up to 24 days in open field tests against A. brassicae .