Enantionselektive Synthese des L‐Threonins

An Enantionselective Synthesis of L‐Threonine An enantioselective synthesis of L‐threonine (1) is described. Racemic ethyl 2‐acetamido‐3‐oxobutyrate (6) was synthesized from ethyl acetoacetate (2) [4][5] and then transformed to the epimeric optically active alcohols 7a and 7b by microbiological reduction with Saccharomyces rouxii. The Mixture 7a/7b could be converted to 1 by slightly modified, known Methods in a yield of ca. 52% with respect to 7a/7b.