A peroxidase-labeled antibody technique revealed von Willebrand factor antigen (vWF:Ag) in rough endoplasmic reticulum (rER), the perinuclear region, and the cytoplasmic vesicles of capillary endothelial cells in oral mucosa. After administration of epinephrine or 1-deamino-8-D- arginine vasopressin (DDAVP), the localization of vWF:Ag was shown to have changed to the basement membrane and the surrounding interstitium. This change of vWF:Ag localization induced by epinephrine and DDAVP may play a role in the adhesion of platelets to subendothelium following endothelial injury during surgery and may be an unknown hemostatic effect of these drugs.
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Takeuchi et al. (1988) studied this question.
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