Novel strategies to retard renal disease progression: combining ACE inhibition with endothelin receptor blocking?
Key result
Combining ACE inhibition with endothelin receptor blocking is explored as a potential novel strategy to retard the progression of renal disease.
Why the study?
Does combining ACE inhibition with endothelin receptor blocking retard renal disease progression?
Design
Review
Authors
Discussion
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Member takes
Implication
Dual blockade merits prospective RCTs; leaves open additive renoprotection versus ACE inhibition alone in progressive renal disease.
Structured PICO
Does combining ACE inhibition with endothelin receptor blocking retard renal disease progression?
I
Intervention
Combining ACE inhibition with endothelin receptor blocking
O
Outcome
Renal disease progression
This paper discusses the potential of combining ACE inhibition with endothelin receptor blocking to retard renal disease progression.
Cite This Study
Benigni et al. (1998) studied this question. Combining ACE inhibition with endothelin receptor blocking is explored as a potential novel strategy to retard the progression of renal disease.