High-throughput sequencing identifies an NFIA/CBFA2T3 fusion gene in acute erythroid leukemia with t(1;16)(p31;q24)

In a previous publication of ours 1 we showed the involvement of the myeloid translocation gene-related protein 2 gene ( CBFA2T3 ) in a case of acute erythroid leukemia with the translocation t(1;16)(p31;q24). Because of lack of material available for analysis, we could not with certainty determine the leukemogenic mechanism, whether it be generation of a fusion gene with CBFA2T3 as one of the partners or loss of tumor suppressor activity, in which case genes KANK1 and L1TD1 , both homozygously lost, might be of the essence.