Asymmetric Hydrogenation of Heteroarenes with Multiple Heteroatoms

Enantiopure heterocyclic architectures containing two or more heteroatoms in the ring system have attracted considerable attraction due to this motif playing a role of great importance in asymmetric synthesis and the pharmaceutical chemistry. This review focused on recent advances in the homogeneous asymmetric hydrogenation of heteroarenes with multiple heteroatoms, which provide an efficient and practical method to structural diverse chiral heterocyclic compounds. 1 Introduction 2 Asymmetric Hydrogenation of Five-Membered-Ring Hetero­arenes 2.1 Imidazoles and Oxazoles 2.2 Pyrazole Derivatives 2.3 Benzisoxazoles 3 Asymmetric Hydrogenation of Six-Membered-Ring Heteroarenes 3.1 Quinoxalines 3.2 Quinazolines 3.3 Pyrimidines 3.4 Pyrazines 4 Asymmetric Hydrogenation of Fused Nitrogen Heteroarenes 4.1 Heteroarenes Containing a Ring-Junction Nitrogen 4.2 Heteroarenes Containing a Fused Pyridine Ring 5 Conclusions and Outlook