Transverse lipid migration (flip-flop) of 2-F, a head-group-labeled dipalmitoylphosphatidylcholine (DPPC), in surface-differentiated 1:7 coliposomes with unlabeled DPPC ( 2-NF ), is facilitated by added N -isopropylacrylamide (NIPAM) polymers at temperatures above the extended → contracted transition temperatures of the polymers (30−33 °C). The effectiveness of the polymers is sensitive to the identity of the substituents on their amide nitrogens; an octadecyl residue is particularly potent, whereas a butylpyrenyl substituent is ineffective. Evidence is also presented for interliposomal polymer transfer above the liposomes' gel → liquid crystal transition temperature.
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Bhattacharya et al. (1997) studied this question.
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