Improved immunological profile of HIV infected patients with renal abnormalities on antiretroviral therapy

: Kidney damage appears to be a common complication of HIV infection in the modern era of antiretroviral therapy (ART).This cross sectional study evaluate the pattern, nature and character of elevation of two basic renal safety parameters (urinary uric acid and glucose) in over 57 HIV-infected patients exposed to tenofovir (TDF) (21), non-TDF (21) and drug naïve (15) patients. : Urinary uric acid and glucose were assessed at commencement (V1) and after 4wks (V2), and after 12wks (V3) of patient exposure to therapy. Clinical features of both groups were comparable at commencement. Uricosuria and glucosuria were defined as urinary uric acid and glucose; ≥0.1mg/dl and ≥1.0 mg/dl respectively. : After 12 weeks of follow-up incidence of uricosuria and glucosuria were as as follows: [TDF (9), non-TDF (2) and drug naïve (3) (p=0.000)] and [TDF (9), non-TDF (3) and drug naïve (1) (p=0.000)] respectively. Fractional excretion of uric acid was also altered in the two treatment groups. : The results show that treatment of HIV-infected patients with a TDF-based regimen compared to a non-TDF-based regimen produce alterations in safety biomarkers of renal pathophysiologic parameters (creatinine, glucosuria, Uricosuria and CD4) after a 12-weeks treatment period. In conclusion, TDF may be associated with subclinical renal tubular damage, inducing at a later stage major increased in urinary excretion of glucose and uric acid, as markers of early tubular injury.