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Commentary highlights methodological considerations in a meta-analysis of tegoprazan–amoxicillin dual therapy for Helicobacter pylori, suggesting careful interpretation of findings.
A Systematic Review and Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials" by Zhou et al. published in the Journal of Gastroenterology and Hepatology [1].We appreciate the authors for conducting this systematic review and meta-analysis with trial sequential analysis, which synthesizes evidence from randomized controlled trials to provide a more robust evaluation of tegoprazan-amoxicillin dual therapy for H. pylori eradication.However, several methodological considerations warrant further consideration.
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Saqib et al. (2026) studied this question.
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