What does this research mean for the field?

Shen-Ling-Bai-Zhu-San (SLBZS) alleviates antibiotic-associated diarrhea in juvenile rats by modulating gut microbiota, particularly Parabacteroides distasonis, and altering metabolites associated with the ABC transporter pathway. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the therapeutic effects and underlying biological mechanisms of Shen-Ling-Bai-Zhu-San decoction on gut microbiota and fecal metabolites in juvenile rats with antibiotic-associated diarrhea.

September 10, 2026International MicrobiologyOpen Access

Gut microbiota and ABC transporter pathway: potential links to the therapeutic efficacy of Shen-Ling-Bai-Zhu-San against antibiotic-associated diarrhea in juvenile rats

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To investigate the therapeutic effects and underlying biological mechanisms of Shen-Ling-Bai-Zhu-San decoction on gut microbiota and fecal metabolites in juvenile rats with antibiotic-associated diarrhea.
Randomly assigned juvenile rats to control, model, and Shen-Ling-Bai-Zhu-San intervention groups.
Induced antibiotic-associated diarrhea via oral antibiotic cocktail gavage, followed by Shen-Ling-Bai-Zhu-San decoction administration while monitoring body weight and fecal consistency.
Profiled fecal microbiota using 16S rDNA sequencing and characterized metabolic alterations using widely targeted metabolomics and correlation analysis.
Shen-Ling-Bai-Zhu-San significantly decreased diarrhea incidence and improved fecal consistency scores compared to untreated model rats.
Treatment reversed antibiotic-induced dysbiosis by favorably modulating the relative abundances of Muribaculaceae, Tannerellaceae, Parabacteroides, and Parabacteroides distasonis.
Fecal metabolomics identified 29 favorably regulated differential metabolites, including 11 enriched in the ABC transporter pathway and 5 ABC-related metabolites that strongly correlated with Parabacteroides distasonis abundance.

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Implication

Randomized experimental study demonstrates that Shen-Ling-Bai-Zhu-San alleviates antibiotic-associated diarrhea in juvenile rats, indicating gut microbiota and ABC transporter pathway modulation.

Cite This Study

Yan et al. (2026) studied this question.

synapsesocial.com/papers/6aa27a7f58559d80afc731cf https://doi.org/10.1007/s10123-026-00891-4

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Implication

Randomized experimental study demonstrates that Shen-Ling-Bai-Zhu-San alleviates antibiotic-associated diarrhea in juvenile rats, indicating gut microbiota and ABC transporter pathway modulation.

Gut microbiota and ABC transporter pathway: potential links to the therapeutic efficacy of Shen-Ling-Bai-Zhu-San against antibiotic-associated diarrhea in juvenile rats

Key Points

Discussion

Implication

Cite This Study

Gut microbiota and ABC transporter pathway: potential links to the therapeutic efficacy of Shen-Ling-Bai-Zhu-San against antibiotic-associated diarrhea in juvenile rats

Key Points

Discussion

Implication

Cite This Study

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