What does this research mean for the field?

Early oncofertility counseling and individualized fertility risk assessment must be integrated into routine neuro-oncology care for women with central nervous system tumors to mitigate the reproductive toxicity of treatments. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To review the mechanisms of treatment-related reproductive impairment, established fertility preservation strategies, and pregnancy management in adolescent and young adult women with central nervous system tumors.

September 10, 2026Expert Review of Anticancer Therapy

Fertility preservation in women with central nervous system tumors

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To review the mechanisms of treatment-related reproductive impairment, established fertility preservation strategies, and pregnancy management in adolescent and young adult women with central nervous system tumors.
Conducted a narrative literature search in PubMed covering publications up to March 2026.
Synthesized evidence from prospective and retrospective studies, systematic reviews, meta-analyses, clinical practice guidelines, and relevant case reports.
Identified critical contributors to fertility loss in neuro-oncology, including hypothalamic-pituitary-gonadal axis disruption from cranial irradiation, uterine or ovarian radiation scatter from spinal therapy, and ovarian toxicity induced by alkylating chemotherapy.
Confirmed oocyte and embryo cryopreservation as standard fertility preservation modalities, while highlighting significant evidence gaps regarding the gonadotoxicity of newer neuro-oncology therapies and maternal-fetal outcomes during pregnancy.

Discussion

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Implication

Narrative review reveals substantial treatment-related reproductive risks in women with central nervous system tumors, highlighting the need for early fertility preservation and counseling.

Cite This Study

Tosoni et al. (2026) studied this question.

synapsesocial.com/papers/6aa27a8e58559d80afc7341f https://doi.org/10.1080/14737140.2026.2731197

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Implication

Narrative review reveals substantial treatment-related reproductive risks in women with central nervous system tumors, highlighting the need for early fertility preservation and counseling.

Fertility preservation in women with central nervous system tumors

Key Points

Discussion

Implication

Cite This Study

Fertility preservation in women with central nervous system tumors

Key Points

Discussion

Implication

Cite This Study

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