The skin as a reservoir for Candidozyma auris : colonization dynamics, host defense, and decolonization challenges

Q: What does this research mean for the field?

Experimental models, including murine, porcine, and human skin systems, are critical for understanding Candidozyma auris colonization dynamics, host-pathogen interactions, and the efficacy of decolonization strategies, though significant knowledge gaps remain. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Débora Silva Marques de Sousa; Ana Karla Lima Freire Cabral; Bruno Bulgarelli Adorno Arantes; Júlia Hatsue Araújo Sato; Gabrielle Pires de Morais Monari; Luciana da Silva Ruiz; Yehia Elgammal; Luis R. Martinez; Ana Marisa Fusco‐Almeida; Maria José Soares Mendes‐Giannini

doi:10.1080/1040841x.2026.2727050

September 8, 2026Critical Reviews in Microbiology

The skin as a reservoir for Candidozyma auris : colonization dynamics, host defense, and decolonization challenges

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Key Points

Review the mechanisms of skin colonization, host immune responses, and decolonization barriers for Candidozyma auris using preclinical skin models.
Evaluated findings from experimental murine, porcine, and human skin model systems.
Assessed host-pathogen interactions, cutaneous immune defenses, and the efficacy of topical antifungal and decolonization protocols.
Experimental skin models demonstrate persistent Candidozyma auris adherence, deep epidermal residence, and evasion of cutaneous immune defenses.
Antifungal agents and standard topical antiseptics show variable and often incomplete decolonization efficacy, highlighting key knowledge gaps for clinical infection control.

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Implication

Narrative review reveals skin colonization dynamics of Candidozyma auris in experimental skin models, highlighting substantial challenges in antifungal decolonization strategies.

Abstract

, with emphasis on experimental models (i.e. murine, porcine, and human skin systems) that have advanced our understanding of host-pathogen interactions, immune responses, and the efficacy of antifungal and decolonization strategies, highlighting critical knowledge gaps and future research priorities.

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Sousa et al. (2026) studied this question.

synapsesocial.com/papers/6aa27a9f58559d80afc7356c https://doi.org/10.1080/1040841x.2026.2727050

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The skin as a reservoir for Candidozyma auris : colonization dynamics, host defense, and decolonization challenges

Key Points

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Implication

Abstract

Discussion

Cite This Study

The skin as a reservoir for Candidozyma auris : colonization dynamics, host defense, and decolonization challenges

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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