Narrative review reveals skin colonization dynamics of Candidozyma auris in experimental skin models, highlighting substantial challenges in antifungal decolonization strategies.
Key Points
Review the mechanisms of skin colonization, host immune responses, and decolonization barriers for Candidozyma auris using preclinical skin models.
Evaluated findings from experimental murine, porcine, and human skin model systems.
Assessed host-pathogen interactions, cutaneous immune defenses, and the efficacy of topical antifungal and decolonization protocols.
Experimental skin models demonstrate persistent Candidozyma auris adherence, deep epidermal residence, and evasion of cutaneous immune defenses.
Antifungal agents and standard topical antiseptics show variable and often incomplete decolonization efficacy, highlighting key knowledge gaps for clinical infection control.