Synthesis of peripheral octa-4-[(6-bromonaphthalene-2-yl)oxy] substituted Co II , Cu II , Mn III (Cl) phthalocyanines and investigation of spectral, aggregation, total antioxidant status, total oxidant status and oxidative stress index properties

This study focuses on the synthesis, characterization, and investigation of the effects of new cobalt, copper, and manganese phthalocyanine complexes substituted at the peripheral positions with octa-4-[(6-bromonaphthalen-2-yl)oxy] groups on the oxidative balance in biological systems. The structures of these newly synthesized derivatives were confirmed using FT-IR, UV-Vis, and MALDI-TOF mass spectroscopy, and their spectral and aggregation properties in various solvents were extensively examined. The broad π-conjugated systems of phthalocyanines and the type of central metal atom directly influence their free radical scavenging and antioxidant capacities. In this context, the impact of the peripheral bromonaphthyl groups and metal center on the total antioxidant potential was quantitatively evaluated using total antioxidant status, total oxidant status, and oxidative stress index parameters. The findings indicate that the octa-4-[(6-bromonaphthalen-2-yl)oxy] substitution shapes the biological activities of the compounds by affecting their solubility and aggregation tendencies. This study provides significant data regarding the potential use of these specifically designed metallophthalocyanines as promising candidates for future studies on oxidative stress-related applications.