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September 10, 2026Journal of the American Statistical Association

Guided Adversarial Robust Transfer Learning with Source Mixing

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Authors

XXXin XiongZGZijian GuoTCTianxi Cai

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Overview

Computational study demonstrates improved robustness and accuracy for adversarial transfer learning in multi-institutional biobanks, indicating enhanced prediction under limited target data.

Key Points

  • To develop a transfer learning framework that leverages diverse auxiliary sources without requiring strict distributional similarity to target data.
  • Formulated Guided Adversarial Robust Transfer (GART) learning to optimize adversarial loss over mixtures of auxiliary source distributions and derived theoretical convergence guarantees.
  • Evaluated performance using comparative numerical simulations and applied the model to genetic prediction of high-density lipoprotein cholesterol using multi-institutional biobank-linked electronic health records.
  • Derived the closed-form population GART estimator, demonstrating a faster theoretical convergence rate than estimators relying exclusively on target data.
  • Simulation analyses showed that GART achieved higher robustness and predictive accuracy than existing transfer learning benchmarks.
  • Successfully constructed genetic risk prediction models for high-density lipoprotein cholesterol across multi-institutional health datasets.

Cite This Study

Xiong et al. (2026) studied this question.

synapsesocial.com/papers/6aa27ab158559d80afc73665https://doi.org/10.1080/01621459.2026.2675620
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