What does this research mean for the field?

Improper administration of oral bisphosphonates in patients with cognitive impairment or dysphagia can lead to severe oral mucosal chemical injury, necessitating pre-treatment assessments and alternative antiresorptive therapies. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To document a case of oral mucosal chemical injury caused by retained bisphosphonate tablets in an older adult with advanced dementia and unassessed dysphagia.

September 10, 2026GeriatricsOpen Access

Burning Questions: Oral Ulceration Secondary to Improper Bisphosphonate Administration in Advanced Dementia

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Authors

KMKate Murphy EMEleanor Marks KOKieran O’Connor

Discussion

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Overview

Case report reveals severe oral ulceration from retained ibandronate in dementia, highlighting the need for swallowing assessments before prescribing oral bisphosphonates.

Key Points

To document a case of oral mucosal chemical injury caused by retained bisphosphonate tablets in an older adult with advanced dementia and unassessed dysphagia.
Clinical case evaluation of a 73-year-old female nursing home resident with advanced vascular dementia presenting with acute oral pain, lip ulceration, and facial swelling while receiving monthly ibandronic acid (150 mg).
Comprehensive diagnostic assessment by hospital dental services, including mucosal evaluation and exclusion of hematinic deficiency, trauma, malignancy, and osteonecrosis.
Examination identified severe chemical mucosal ulceration of the left lower lip and anterior tongue linked temporally to retained oral ibandronic acid.
Cessation of ibandronic acid and initiation of topical therapy resulted in complete resolution of oral ulcerations within three weeks, facilitating a safe transition to denosumab.

Cite This Study

Murphy et al. (2026) studied this question.

synapsesocial.com/papers/6aa27ab158559d80afc737cb https://doi.org/10.3390/geriatrics11050128

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September 10, 2026GeriatricsOpen Access

Burning Questions: Oral Ulceration Secondary to Improper Bisphosphonate Administration in Advanced Dementia

View Full Paper

Ask AI

Bookmark

Authors

KMKate Murphy EMEleanor Marks KOKieran O’Connor

Discussion

Member takes

Overview

Case report reveals severe oral ulceration from retained ibandronate in dementia, highlighting the need for swallowing assessments before prescribing oral bisphosphonates.

Key Points

To document a case of oral mucosal chemical injury caused by retained bisphosphonate tablets in an older adult with advanced dementia and unassessed dysphagia.
Clinical case evaluation of a 73-year-old female nursing home resident with advanced vascular dementia presenting with acute oral pain, lip ulceration, and facial swelling while receiving monthly ibandronic acid (150 mg).
Comprehensive diagnostic assessment by hospital dental services, including mucosal evaluation and exclusion of hematinic deficiency, trauma, malignancy, and osteonecrosis.
Examination identified severe chemical mucosal ulceration of the left lower lip and anterior tongue linked temporally to retained oral ibandronic acid.
Cessation of ibandronic acid and initiation of topical therapy resulted in complete resolution of oral ulcerations within three weeks, facilitating a safe transition to denosumab.

Cite This Study

Murphy et al. (2026) studied this question.

synapsesocial.com/papers/6aa27ab158559d80afc737cb https://doi.org/10.3390/geriatrics11050128

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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