Systematic review and meta-analysis finds fine-needle aspiration outperforms exfoliative cytology for pulmonary salivary gland-type tumors, indicating superior preoperative utility.
Key Points
To evaluate the effectiveness and cytohistologic concordance of cytologic evaluations in diagnosing rare primary pulmonary salivary gland-type tumors.
Conducted a systematic search of the PubMed database to identify studies with both cytologic and histologic diagnostic data on primary pulmonary salivary gland-type tumors.
Extracted individual patient-level data across 49 studies encompassing 106 patients and performed meta-analyses using OpenMeta[Analyst] software.
Overall cytohistologic concordance between preoperative cytology and final histology was 48.1% across 106 cases.
Fine-needle aspiration yielded the highest diagnostic sensitivity at 75.0%, compared with 38.1% for bronchial/tracheal washing and 34.2% for bronchial brushing.
Adenoid cystic carcinoma represented the majority of confirmed diagnoses (67 cases), followed by mucoepidermoid carcinoma (27 cases).