Encapsulation of Sucralose Into Cyclodextrin Metal–Organic Frameworks: Preparation, Structure Characterization, and Evaluation of Thermal Stability

Electronic cigarettes (e‐cigarettes) have acquired more popularity in recent years, mainly because they are supposed to be less harmful than regular cigarettes. The thermal stability of sucralose (Suc) as sweetener in e‐cigarettes is important. This study aimed to synthesize sucrose loaded cyclodextrin‐metal–organic frameworks (CD‐MOFs) from potassium hydroxide, crystallized with β‐cyclodextrin (β‐CD) and γ‐CD, and their complex thermal stability properties were further evaluated. The basic β‐CD MOFs reaches high sucrose payloads of 92.54 wt%, corresponding to a molar ratio of 8:1 between sucrose and β‐CD. Thermal stability analysis indicates a substantial improvement, with the Suc‐β‐CD‐MOF complexes displaying an onset decomposition temperature of 197°C, representing a 125°C increase relative to that of free sucrose. In comparison to Suc‐β‐CD‐MOF, sucrose coated with β‐CD‐MOF maintained 73.4% at 80°C for 12 h, with the release rate reduced by about 26.6%. These findings demonstrate the potential of β‐CD‐MOF as effective carriers for sucrose thermal stability enhancement.