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September 10, 2026Nutrition in Clinical Practice

Intestinal failure in children receiving home parenteral nutrition: A Korean multicenter retrospective study

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Authors

SPSun Woo ParkSeoul National University Children's HospitalKLKyung Jae LeeSeoul National UniversityLKLia KimSeoul National University

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Implication

Multicenter retrospective study reveals persistent growth failure and high dependency in children receiving home parenteral nutrition, highlighting challenges in achieving enteral autonomy.

Key Points

  • To investigate the clinical characteristics, complications, and nutritional outcomes of pediatric patients with intestinal failure receiving home parenteral nutrition.
  • Nationwide multicenter retrospective study conducted across 10 tertiary hospitals in Korea between April 2023 and June 2024.
  • Enrolled 51 pediatric patients (median age 8.4 years) who initiated parenteral nutrition at ≤18 years of age and were receiving home parenteral nutrition.
  • Evaluated catheter-related bloodstream infections, intestinal failure-associated liver disease, micronutrient status, and anthropometric Z-scores from initiation to study enrollment.
  • The primary etiologies were chronic intestinal pseudo-obstruction (51%) and short bowel syndrome (39%), with a median parenteral nutrition duration of 7.7 years.
  • Complications included at least one catheter-related bloodstream infection in 70.6% of patients (1.57 per 1,000 catheter days), liver disease in 41.2%, catheter thrombosis in 17.6%, and prevalent vitamin D deficiency.
  • Patients demonstrated persistent growth failure, and 52.9% maintained a parenteral nutrition dependency ratio of ≥75% at enrollment, indicating limited enteral autonomy.

Cite This Study

Park et al. (2026) studied this question.

synapsesocial.com/papers/6aa27afb58559d80afc73ed6https://doi.org/10.1002/ncp.70178
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