What does this research mean for the field?

Altered mental status in COVID-19 patients is independently associated with higher mortality, increased need for intensive care unit admission, and mechanical ventilation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess the clinical characteristics, disease severity, and in-hospital mortality associated with altered mental status at presentation in patients hospitalized with COVID-19.

September 10, 2026The Egyptian Journal of Critical Care MedicineOpen Access

Hospital course and outcomes of COVID-19 patients presenting with altered sensorium

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Authors

JBJamil Muqtadir Bhatti SRSyed Ali Raza IBIrshad Batool

Discussion

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Overview

Retrospective cohort study reveals increased mortality and critical care utilization in COVID-19 patients with altered mental status, highlighting the prognostic value of baseline neurological signs.

Key Points

To assess the clinical characteristics, disease severity, and in-hospital mortality associated with altered mental status at presentation in patients hospitalized with COVID-19.
Conducted a retrospective cohort study of 1,185 COVID-19 patients admitted over a 40-month period to a tertiary care hospital in Karachi, Pakistan.
Assessed clinical features, underlying etiologies, and outcomes using multivariable regression and an adjusted Cox proportional hazards survival analysis.
Altered mental status was present in 17.1% (203/1,185) of patients at admission, most commonly caused by encephalopathy, hyponatremia, and stroke.
Patients with altered mental status had significantly higher rates of in-hospital mortality (34.5% vs. 21.9%), intensive care unit admission (30.5% vs. 9.7%), and invasive mechanical ventilation (19.2% vs. 5.1%).
Altered mental status remained independently associated with increased in-hospital mortality in adjusted survival analysis (aHR 1.560, 95% CI 1.166–2.087, P = 0.003).

Cite This Study

Bhatti et al. (2026) studied this question.

synapsesocial.com/papers/6aa27b2658559d80afc742ec https://doi.org/10.1007/s44349-026-00062-4

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September 10, 2026The Egyptian Journal of Critical Care MedicineOpen Access

Hospital course and outcomes of COVID-19 patients presenting with altered sensorium

View Full Paper

Ask AI

Bookmark

Authors

JBJamil Muqtadir Bhatti SRSyed Ali Raza IBIrshad Batool

Discussion

Member takes

Overview

Retrospective cohort study reveals increased mortality and critical care utilization in COVID-19 patients with altered mental status, highlighting the prognostic value of baseline neurological signs.

Key Points

To assess the clinical characteristics, disease severity, and in-hospital mortality associated with altered mental status at presentation in patients hospitalized with COVID-19.
Conducted a retrospective cohort study of 1,185 COVID-19 patients admitted over a 40-month period to a tertiary care hospital in Karachi, Pakistan.
Assessed clinical features, underlying etiologies, and outcomes using multivariable regression and an adjusted Cox proportional hazards survival analysis.
Altered mental status was present in 17.1% (203/1,185) of patients at admission, most commonly caused by encephalopathy, hyponatremia, and stroke.
Patients with altered mental status had significantly higher rates of in-hospital mortality (34.5% vs. 21.9%), intensive care unit admission (30.5% vs. 9.7%), and invasive mechanical ventilation (19.2% vs. 5.1%).
Altered mental status remained independently associated with increased in-hospital mortality in adjusted survival analysis (aHR 1.560, 95% CI 1.166–2.087, P = 0.003).

Cite This Study

Bhatti et al. (2026) studied this question.

synapsesocial.com/papers/6aa27b2658559d80afc742ec https://doi.org/10.1007/s44349-026-00062-4

View Full Paper

Ask AI

Bookmark