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September 10, 2026Radiology Case ReportsOpen Access

“Ears of the lynx” sign on MRI: A radiologic clue to hereditary spastic paraplegia

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Authors

IBIbtissam El BqaqZIZineb IziNKNajwa Ech-Cherif Kettani

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Overview

Case report reveals the 'ears of the lynx' MRI sign in siblings with complicated hereditary spastic paraplegia, highlighting a critical diagnostic biomarker when genetic testing is inaccessible.

Key Points

  • Describe the clinical and neuroimaging presentation of complicated hereditary spastic paraplegia in siblings to assess the diagnostic value of specific radiologic biomarkers.
  • Evaluated two male siblings born to consanguineous parents presenting with complicated hereditary spastic paraplegia (N=2).
  • Conducted brain magnetic resonance imaging (MRI) using T2 and FLAIR sequences to characterize central nervous system structural abnormalities.
  • Brain MRI demonstrated thinning of the corpus callosum and cone-shaped T2/FLAIR hyperintensities at the anterior horns of the lateral ventricles ('ears of the lynx' sign).
  • The radiologic findings directly linked the patients' phenotype to SPG11 and SPG15 genetic subtypes of complicated hereditary spastic paraplegia.

Cite This Study

Bqaq et al. (2026) studied this question.

synapsesocial.com/papers/6aa27b2658559d80afc74331https://doi.org/10.1016/j.radcr.2026.08.031
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