Literature review reveals associations between interleukin-6 promoter polymorphisms and disease susceptibility, indicating their potential utility as ethnic-specific biomarkers.
Interleukin 6 (IL‐6), a type of cytokine, plays a role in the onset, progression, and prognosis of various diseases. IL‐6's single nucleotide polymorphisms (SNPs) markedly affect clinical conditions by influencing gene expression, including that of other cytokines. This review synthesizes existing literature to explore the relationship between IL‐6 SNPs and diseases. Current evidence indicates that these SNPs are associated with the clinicopathological features of different diseases, with these associations partly influenced by population ethnicity. Although IL‐6 SNPs could potentially serve as biomarkers for disease susceptibility and progression, larger‐scale studies across diverse regions and populations are required to confirm their clinical significance.
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Li et al. (2026) studied this question.
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