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September 10, 2026Scandinavian Journal of Primary Health CareOpen Access

Alcohol consumption is linked to a ~41% higher myocardial infarction risk upon independent data recalculation.

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Key result

Independent recalculation of published data revealed alcohol consumption yielded an odds ratio of 1.41 for myocardial infarction, contradicting the originally reported OR of 0.57.

Authors

GKGeorge KoulaouzidisAKAnastasios Koulaouzidis

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Overview

Reanalysis reveals conflicting risk estimates for myocardial infarction in automotive workers, indicating alcohol confers no cardioprotection.

Key Points

  • To assess the internal consistency, statistical calculations, and interpretation of reported outcomes in a 30-year cohort study examining alcohol consumption and cardiovascular events.
  • Conducted a critical commentary and independent recalculation of odds ratios from published aggregate data.
  • Evaluated follow-up data from a Swedish occupational cohort of 973 male automotive workers monitored over 30 years for myocardial infarction, stroke, and all-cause mortality.
  • The published abstract cited an odds ratio of 0.57 for myocardial infarction, but direct recalculation from reported data counts yielded an odds ratio of 1.41, with 0.57 corresponding instead to all-cause mortality.
  • Re-evaluation identified multiple inconsistencies across tables and figures, inappropriate survival-time terminology, and unaddressed residual confounding including sick-quitter bias, failing to demonstrate cardioprotective or survival benefits.

PICO

P
Population
973 male automotive workers from a Swedish occupational cohort followed for 30 years to assess alcohol consumption and cardiovascular outcomes.
E
Exposure / Comparator
Alcohol consumption
O
Primary Outcome
Myocardial infarction — OR 1.41

Main Result

Odds Ratio: 1.41

Limitations

  • Survival-time terminology
  • Numerical inconsistencies across tables and figures
  • Competing-risk methods
  • Multiplicity
  • Residual confounding, including sick-quitter bias

Cite This Study

Koulaouzidis et al. (2026) studied cardiovascular outcomes (n=973). Alcohol consumption was evaluated on Myocardial infarction (OR 1.41). Independent recalculation of published data revealed alcohol consumption yielded an odds ratio of 1.41 for myocardial infarction, contradicting the originally reported OR of 0.57.

synapsesocial.com/papers/6aa27ba958559d80afc750fahttps://doi.org/10.1080/02813432.2026.2728001
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